THR reports NBCUniversal has decided to cancel the series, which was based on the 2010 Paul Bettany film Legion.
“Led by [series creator] Vaun Wilmott, the talented cast, producers, writers and crew of Dominion have done a tremendous job bringing this ambitious, cinematic series to the screen over the past two seasons," said a Syfy in a statement. "We thank them, as well as our producing partners Universal Cable Productions, Bold Films and Film Afrika.”
A reason given for the cancellation of Dominion is that the ratings dropped by 47 percent in the coveted adult 18-49 advertising demographic.
The report also mentions the future of Defiance is up in the air.
While Dominion has been cancelled, SyFy still has a plethora of science-ficiton shows in the works with The Expanse and Childhood's End coming this December; The Magicians and Hunters are due out in 2016, and new seasons of 12 Monkeys, Killjoys and Dark Matter are in the works.
It's also stated the David Goyer Superman prequel series, Krypton, is still in development, as well as Ben Affleck and Matt Damon's Incorporated; Hyperion, Brave New World and The Final Odyssey.