The Hollywood Reporter reports that actor Irrfan Khan has been signed on to play another villain, "Van Atter" in addition to Rys Ifans who is rumored to play The Lizard. Annie Parisse is said to play Khan's wife.
"Van Atter" could be a reference to the comic book character Nels Van Adder - the Proto-Goblin! Van Adder worked under Osborn as a research scientist and volunteered to be a test subject for a chemical developed by Osborn. However, a stabilizing agent wasn't developed yet with the experiment causing Van Adder to kill, which led to differences between him and Osborn. Eventually, he was hunted by Gwen Stacey's father, Captain George Stacey a policeman and his brother Arthur, Norman's head of security. As the Proto-Goblin attempted to kill Norman, he was attacked by George and Arthur and believed dead when thrown out a window and into the river. His body was never found.
In related news, it looks like Peter Parker's Mom and Dad will be appearing in the Spider-Man Movie as the Reporter said Cambell Scott and Julianne Nicholson have been signed on to play them. No word if it will be in the form of a flash back scene or a "live" role.