Previously, Portman and the Wachowski's worked together on V For Vendetta, of which Portman starred as Evey, the protege to Hugo Weaving's "V."
Jupiter Ascending, from Warner Bros., is being described as an epic sci-fi franchise, and it was previously reported that the Wachowski's had been looking for "A-List" talent for the movie.
24 Frames states, "the actress has been courted by Lana and Andy Wachowski to star in 'Jupiter Ascending,' the science-fiction movie the filmmakers aim to shoot when they finish cutting their much-anticipated 'Cloud Atlas.' Portman, the person said, was seriously weighing taking the part."
Jupiter Ascending is said to begin production this Fall; however, Portman is signed on for Thor 2, which has a release date of May 2013 and has yet to begin filming. Sounds like there quite possibly could be a confict.