All roads lead to next May, at least that is what Marvel has been seemingly teasing.
In addition to what looks to be the Fantastic Four getting cancelled as well as the death of Wolverine, now it's become known that next April's issue of Avengers #44 will be its last.
Retailers were told about a Final Issue Variant (via Bleeding Cool) for Avengers #44, which looks to be released next April, a month before something big happens to the Marvel U.
Everything looks to begin this September in "Time Runs Out" as Hickman's Avengers issues jump forward in time eight months.
Marvel previously teased "Time Runs Out" at a Diamond Retailer convention, with it speculated the new event will be a Marvel Comics reboot. It was also teased that "it" will happen in May 2015 that will force Marvel to do something the company has never done in its 75 years.
More than likely Avengers will get relaunched in some fashion is our guess.