Even though Van Lente and Hotz have the first two issues completed, Marvel has decided not to solicit the book that was focusing on the monsters of the Marvel U. -- with The Destroyer, The Thing, She-Hulk, Karkas, A-Bomb, and The Beast uniting to stop a monstrous threat.
Van Lente announced the cancellation earlier on his twitter when a fan asked about the status of the mini:
"...that series got the axe weeks ago."
As to why there was no "official" announcement regarding the cancellation of the Destroyers mini, since it was never officially solicited, no announcement was made.
"There was no announcement. The book hadn't been solicited yet, and just wouldn't have."
Van Lente then informs readers that the first two issues were just about done.
"The biggest bummer about DESTROYERS was Kyle Hotz had #1-2 pencilled, and it looked grrrrreat. Ah, well. That's showbiz for you."
AS CBR's Robot 6 notes, the cancellation of the Destroyers mini follows the cancellations of Alpha Flight (co-written by Van Lente), Iron Man 2.0, All-Winners Squad, and Victor Von Doom was canceled before its debut as well.
Van Lente did update that he is working on a new Marvel title.
"I'm working on a Marvel book right now with an artist I've long wanted to work with they haven't announced yet."