They discuss playing the characters, with Emma Stone mentioning her Gwen is a little different compared to the comics.
Director Marc Webb discusses first knowing when Andrew Garfield was Peter Parker/Spider-Man, mentioning there were three or four that screen tested for the part.
Andrew Garfield was asked what his take was on Peter Parker, with the actor stating he loved the comics, movies and cartoons. He mentions he was real interested in the orphan perspective - going out looking for his father and finding himself - "One of the many many things that excited me about it," said Garfield.
Rhys Ifans goes into his character, that was just officially announced today, Dr. Curt Connors aka The Lizard. He says he is similar to Parker in that he is lost, as well, and talks about finding himself, albeit in a much different way.
There is a lot more, almost 8 minutes worth. Check it out below.